Differential Expression of Synapsin I and II upon Treatment by Lithium and Valproic Acid in Various Brain Regions.

ABSTRACT:

Introduction

Due to the heterogeneity of psychiatric illnesses and overlapping mechanisms, patients with psychosis are differentially responsive to pharmaceutical drugs. In addition to having therapeutic effects for schizophrenia and bipolar disorder, antipsychotics and mood stabilizers have many clinical applications and are used unconventionally due to their direct and indirect effects on neurotransmitters. Synapsins, a family of neuronal phosphoproteins, play a key regulatory role in neurotransmitter release at synapses. In this study, we investigated the effects of mood stabilizers, lithium, and valproic acid on synapsin gene expression in the rat brain.

Methods

Intraperitoneal injections of saline, lithium, and valproic acid were administered to male Sprague Dawley rats

SUBMITTER: Joshi H 

PROVIDER: S-EPMC6007270 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature