Poly (ethylene glycol) hydrogel elasticity influences human mesenchymal stem cell behavior.

ABSTRACT: Coordinated investigations into the interactions between biologically mimicking (biomimetic) material constructs and stem cells advance the potential for the regeneration and possible direct replacement of diseased cells and tissues. Any clinically relevant therapies will require the development and optimization of methods that mass produce fully functional cells and tissues. Despite advances in the design and synthesis of biomaterial scaffolds, one of the biggest obstacles facing tissue engineering is understanding how specific extracellular cues produced by biomaterial scaffolds influence the proliferation and differentiation of various cell sources. Matrix elasticity is one such tailorable property of synthetic scaffolds that is known to differ between tissues. Here, we investigate the

SUBMITTER: Whitehead AK 

PROVIDER: S-EPMC6007362 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature