Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide.

ABSTRACT:

Background

Brain-derived neurotrophic factor is implicated in the pathophysiology of major depressive disorder and suicide. Both are partly caused by early life adversity, which reduces brain-derived neurotrophic factor protein levels. This study examines the association of brain-derived neurotrophic factor Val66Met polymorphism and brain brain-derived neurotrophic factor levels with depression and suicide. We hypothesized that both major depressive disorder and early life adversity would be associated with the Met allele and lower brain brain-derived neurotrophic factor levels. Such an association would be consistent with low brain-derived neurotrophic factor mediating the effect of early life adversity on adulthood suicide and major depressive disorder.

Methods

Brain-deriv

SUBMITTER: Youssef MM 

PROVIDER: S-EPMC6007393 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature