Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs.

ABSTRACT:

Background

Choline is an essential nutrient that is pivotal to proper brain development. Research in animal models suggests that perinatal choline deficiency influences neuron development in the hippocampus and cortex, yet these observations require invasive techniques.

Objective

This study aimed to characterize the effects of perinatal choline deficiency on gray and white matter development with the use of noninvasive neuroimaging techniques in young pigs.

Methods

During the last 64 d of the 114-d gestation period Yorkshire sows were provided with a choline-sufficient (CS) or choline-deficient (CD) diet, analyzed to contain 1214 mg or 483 mg total choline/kg diet, respectively. Upon farrowing, pigs (Sus scrofa domesticus) were allowed colostrum consumption for

SUBMITTER: Mudd AT 

PROVIDER: S-EPMC6007439 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature