Coupling of replisome movement with nucleosome dynamics can contribute to the parent-daughter information transfer.

ABSTRACT: Positioning of nucleosomes along the genomic DNA is crucial for many cellular processes that include gene regulation and higher order packaging of chromatin. The question of how nucleosome-positioning information from a parent chromatin gets transferred to the daughter chromatin is highly intriguing. Accounting for experimentally known coupling between replisome movement and nucleosome dynamics, we propose a model that can obtain de novo nucleosome assembly similar to what is observed in recent experiments. Simulating nucleosome dynamics during replication, we argue that short pausing of the replication fork, associated with nucleosome disassembly, can be a event crucial for communicating nucleosome positioning information from parent to daughter. We show that the interplay of timescales b

SUBMITTER: Bameta T 

PROVIDER: S-EPMC6007630 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature