Conserved Noncoding Elements Influence the Transposable Element Landscape in Drosophila.

ABSTRACT: Highly conserved noncoding elements (CNEs) constitute a significant proportion of the genomes of multicellular eukaryotes. The function of most CNEs remains elusive, but growing evidence indicates they are under some form of purifying selection. Noncoding regions in many species also harbor large numbers of transposable element (TE) insertions, which are typically lineage specific and depleted in exons because of their deleterious effects on gene function or expression. However, it is currently unknown whether the landscape of TE insertions in noncoding regions is random or influenced by purifying selection on CNEs. Here, we combine comparative and population genomic data in Drosophila melanogaster to show that the abundance of TE insertions in intronic and intergenic CNEs is reduced relat

SUBMITTER: Manee MM 

PROVIDER: S-EPMC6007792 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature