Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets.

ABSTRACT:

Background

Molecular characterization of nonmuscle invasive bladder cancer (NMIBC) may provide a biologic rationale for treatment response and novel therapeutic strategies.

Objective

To identify genetic alterations with potential clinical implications in NMIBC.

Design, setting, and participants

Pretreatment index tumors and matched germline DNA from 105 patients with NMIBC on a prospective Institutional Review Board-approved protocol underwent targeted exon sequencing analysis in a Clinical Laboratory Improvement Amendments-certified clinical laboratory.

Outcome measurements and statistical analysis

Comutation patterns and copy number alterations were compared across stage and grade. Associations between genomic alterations and recurrence after intravesical bac

SUBMITTER: Pietzak EJ 

PROVIDER: S-EPMC6007852 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature