Telomere length and mortality in the Ludwigshafen Risk and Cardiovascular Health study.

ABSTRACT:

Introduction

Short telomeres have been associated with adverse lifestyle factors, cardiovascular risk factors and age-related diseases, including cardiovascular disease (CVD), myocardial infarction, atherosclerosis, hypertension, diabetes, and also with mortality. However, previous studies report conflicting results.

Objectives

The aim of the present study has been to investigate the involvement of telomere length in all-cause and CVD mortality in subjects hospitalized for diagnostic coronary angiography of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

Methods

Relative telomere length (RTL) was measured with a Q-PCR based method in 3,316 participants of the LURIC study. Age-corrected RTL was calculated as the ratio between RTL and age. Median follow-u

SUBMITTER: Pusceddu I 

PROVIDER: S-EPMC6007915 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature