The immunosuppressive face of sepsis early on intensive care unit-A large-scale microarray meta-analysis.

ABSTRACT:

Background

Sepsis is defined as a life-threatening condition, resulting from a dysregulated and harmful response of the hosts' immune system to infection. Apart from this, the (over-)compensating mechanisms counterbalancing the inflammatory response have been proven to render the host susceptible to further infections and increase delayed mortality. Our study aimed to unravel the heterogeneity of immune response in early sepsis and to explain the biology behind it.

Methods

A systematic search of public repositories yielded 949 microarray samples from patients with sepsis of different infectious origin and early after clinical manifestation. These were merged into a meta-expression set, and after applying sequential conservative bioinformatics filtering, an in-deep analysis o

SUBMITTER: Schaack D 

PROVIDER: S-EPMC6007920 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature