Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions.

ABSTRACT: RNA pseudoknots are a kind of minimal RNA tertiary structural motifs, and their three-dimensional (3D) structures and stability play essential roles in a variety of biological functions. Therefore, to predict 3D structures and stability of RNA pseudoknots is essential for understanding their functions. In the work, we employed our previously developed coarse-grained model with implicit salt to make extensive predictions and comprehensive analyses on the 3D structures and stability for RNA pseudoknots in monovalent/divalent ion solutions. The comparisons with available experimental data show that our model can successfully predict the 3D structures of RNA pseudoknots from their sequences, and can also make reliable predictions for the stability of RNA pseudoknots with different lengths and

SUBMITTER: Shi YZ 

PROVIDER: S-EPMC6007934 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature