Genetic polymorphisms in ataxin-3 and liver cirrhosis risk related to aflatoxin B1.

ABSTRACT:

Background

Altered expression of ataxin-3 (AT3) can modify DNA repair capacity and is observed in human diseases. The genetic polymorphisms of this gene in aflatoxin B1 (AFB1)-related liver cirrhosis (LC) have not yet been elucidated.

Materials and methods

We conducted a hospital-based case-control study, including 384 patients with LC and 851 controls without any liver diseases, to assess the association between 264 polymorphisms in AT3 and AFB1-related LC risk. Genotype were tested using TaqMan-PCR or sequencing technique.

Results

We found three differentially distributed SNPs (rs8021276, rs7158733, and rs10146249) via the screening analysis; however, only rs8021276 polymorphism was further identified to modify the risk of LC. Compared with the homozygote of rs80212

SUBMITTER: Wang XZ 

PROVIDER: S-EPMC6007954 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature