Ontology highlight
ABSTRACT:
SUBMITTER: Weng YL
PROVIDER: S-EPMC6007997 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Neuron 20170401 2
Mature neurons in the adult peripheral nervous system can effectively switch from a dormant state with little axonal growth to robust axon regeneration upon injury. The mechanisms by which injury unlocks mature neurons' intrinsic axonal growth competence are not well understood. Here, we show that peripheral sciatic nerve lesion in adult mice leads to elevated levels of Tet3 and 5-hydroxylmethylcytosine in dorsal root ganglion (DRG) neurons. Functionally, Tet3 is required for robust axon regener ...[more]