Novel human genome variants associated with alcohol use disorders identified in a Lithuanian cohort.

ABSTRACT:

Background

Alcohol use disorder (AUD) is a chronic relapsing brain disease characterized by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using (1). Abusive alcohol consumption directly affects a person's physical and psychological health and social life. The World Health Organization has shown that Lithuania is a leading country in pure alcohol consumption in the world (2). The aim of this study is to find novel genome variants that are associated with the AUD in the Lithuanian cohort.

Materials and methods

A case-control study included 294 individuals of Lithuanian ethnicity, who were divided into two groups based on their habits of alcohol use. Single nucleotide polymorphism array analysis was performed using Illumina

SUBMITTER: Baronas K 

PROVIDER: S-EPMC6008003 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature