The cortical cholinergic system contributes to the top-down control of distraction: Evidence from patients with Parkinson's disease.

ABSTRACT: Past animal and human studies robustly report that the cholinergic system plays an essential role in both top-down and bottom-up attentional control, as well as other aspects of cognition (see Ballinger et al., 2016 for a recent review). However, current understanding of how two major cholinergic pathways in the human brain (the basal forebrain-cortical pathway, and the brainstem pedunculopontine-thalamic pathway) contribute to specific cognitive functions remains somewhat limited. To address this issue, we examine how individual variation in the integrity of striatal-dopaminergic, thalamic-cholinergic, and cortical-cholinergic pathways (measured using Positron Emission Tomography in patients with Parkinson's disease) was associated with individual variation in the initial goal-directed fo

SUBMITTER: Kim K 

PROVIDER: S-EPMC6008164 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature