Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.

ABSTRACT: The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular, and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an "omics"-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical, and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical

SUBMITTER: Hampel H 

PROVIDER: S-EPMC6008221 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature