Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain.

ABSTRACT: Secondary bacterial coinfections following influenza virus pose a serious threat to human health. Therefore, it is of significant clinical relevance to understand the immunological causes of this increased susceptibility. Influenza-induced alterations in alveolar macrophages (AMs) have been shown to be a major underlying cause of the increased susceptibility to bacterial superinfection. However, the mechanisms responsible for this remain under debate, specifically in terms of whether AMs are depleted in response to influenza infection or are maintained postinfection, but with disrupted phagocytic activity. The data presented in this article resolves this issue by showing that either mechanism can differentially occur in individual mouse strains. BALB/c mice exhibited a dramatic IFN-γ-depen

SUBMITTER: Califano D 

PROVIDER: S-EPMC6008236 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature