Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery.

ABSTRACT: Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO₂ NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO₂ counterparts in terms of their synthesis method, characterization, doxorubicin (DOX) release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells. Transmission electron microscopy (TEM) of the particles indicated that the fabricated HMSiO₂ NPs had an average diameter of 130 ± 5 nm. Thermogravimetric analysis (TGA) revealed that GSH-sensitive particles had approximately

SUBMITTER: Hadipour Moghaddam SP 

PROVIDER: S-EPMC6008237 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature