Dataset Information

Uniform intratumoral distribution of radioactivity produced using two different radioagents, ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄ and ⁶⁴Cu-ATSM, improves therapeutic efficacy in a small animal tumor model.

ABSTRACT:

Background

The present study proposed a new concept for targeted radionuclide therapy (TRT) to improve the intratumoral distribution of radioactivity using two different radiopharmaceuticals. We examined the efficacy of a combination of a tetrameric cyclic Arg-Gly-Asp (cRGD) peptide-based radiopharmaceutical, ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄ (⁶⁴Cu-RaftRGD, an α_Vβ₃ integrin [α_Vβ₃] tracer), and ⁶⁴Cu-diacetyl-bis (N⁴-methylthiosemicarbazone) (⁶⁴Cu-ATSM, a supposed tracer for hypoxic metabolism) in a small animal tumor model.

Results

Mice with subcutaneous α_Vβ₃-positive U87MG glioblastoma xenografts were used. The intratumoral distribution of a near-inf

SUBMITTER: Jin ZH

PROVIDER: S-EPMC6008272 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Dataset Information

Uniform intratumoral distribution of radioactivity produced using two different radioagents, ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄ and ⁶⁴Cu-ATSM, improves therapeutic efficacy in a small animal tumor model.

Background

Results

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Uniform intratumoral distribution of radioactivity produced using two different radioagents, 64Cu-cyclam-RAFT-c(-RGDfK-)4 and 64Cu-ATSM, improves therapeutic efficacy in a small animal tumor model.

Background

Results

OmicsDI is part of the ELIXIR infrastructure

Tweets

Uniform intratumoral distribution of radioactivity produced using two different radioagents, ⁶⁴Cu-cyclam-RAFT-c(-RGDfK-)₄ and ⁶⁴Cu-ATSM, improves therapeutic efficacy in a small animal tumor model.