CD4⁺ T Cells Have a Permissive Effect on Enriched Environment-Induced Hippocampus Synaptic Plasticity.

ABSTRACT: Living in an enriched environment (EE) benefits health by acting synergistically on various biological systems including the immune and the central nervous systems. The dialog between the brain and the immune cells has recently gained interest and is thought to play a pivotal role in beneficial effects of EE. Recent studies show that T lymphocytes have an important role in hippocampal plasticity, learning, and memory, although the precise mechanisms by which they act on the brain remain elusive. Using a mouse model of EE, we show here that CD4⁺ T cells are essential for spinogenesis and glutamatergic synaptic function in the CA of the hippocampus. However, CD4⁺ lymphocytes do not influence EE-induced neurogenesis in the DG of the hippocampus, by contrast to what we pr

SUBMITTER: Zarif H 

PROVIDER: S-EPMC6008389 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature