Somatic mutations in benign breast disease tissue and risk of subsequent invasive breast cancer.

ABSTRACT: BACKGROUND:Insights into the molecular pathogenesis of breast cancer might come from molecular analysis of tissue from early stages of the disease. METHODS:We conducted a case-control study nested in a cohort of women who had biopsy-confirmed benign breast disease (BBD) diagnosed between 1971 and 2006 at Kaiser Permanente Northwest and who were followed to mid-2015 to ascertain subsequent invasive breast cancer (IBC); cases (n = 218) were women with BBD who developed subsequent IBC and controls, individually matched (1:1) to cases, were women with BBD who did not develop IBC in the same follow-up interval as that for the corresponding case. Targeted sequence capture and sequencing were performed for 83 genes of importance in breast cancer. RESULTS:There were no significant case-control dif

SUBMITTER: Rohan TE 

PROVIDER: S-EPMC6008400 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature