Agrin has a pathological role in the progression of oral cancer.

ABSTRACT: BACKGROUND:The extracellular matrix modulates the hallmarks of cancer. Here we examined the role of agrin-a member of this matrix-in progression of oral squamous cell carcinoma (OSCC). METHODS:We evaluated the immunohistochemical expression of agrin in OSCC and dysplasias. Benign lesions were used as control. In subsequent experiments, we investigated whether the silencing of agrin interferes with tumour expansion both in vitro as well as in vivo. To gain insights into the role of agrin, we identified its protein network (interactome) using mass spectrometry-based proteomics and bioinformatics. Finally, we evaluated the clinical relevance of agrin interactome. RESULTS:Agrin was elevated in malignant and premalignant lesions. Further, we show that agrin silencing interferes with cancer cell

SUBMITTER: Rivera C 

PROVIDER: S-EPMC6008410 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature