Neuroimaging-informed phenotypes of suicidal behavior: a family history of suicide and the use of a violent suicidal means.

ABSTRACT: The identification of brain markers of suicidal risk is highly expected. However, neuroimaging studies have yielded mixed results, possibly due to phenotypic heterogeneity. In the present study, we addressed this issue using structural brain imaging. First, two independent samples of suicide attempters (n = 17 in Montreal, 32 in Jena), patient controls (n = 26/34), and healthy controls (n = 66/34) were scanned with magnetic resonance imaging. Groups were compared with FSL. We then reviewed the literature and run a GingerALE meta-analysis of 12 structural imaging studies comparing suicide attempters and patient controls with whole-brain analyses (n = 693). Finally, we explored the potential contribution of two variables previously associated with biological/cognitive deficits: a family hist

SUBMITTER: Jollant F 

PROVIDER: S-EPMC6008434 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature