Cell wall associated protein TasA provides an initial binding component to extracellular polysaccharides in dual-species biofilm.

ABSTRACT: Many bacteria in biofilm surround themselves by an extracellular matrix composed mainly of extracellular polysaccharide (EP), proteins such as amyloid-like fibers (ALF) and nucleic acids. While the importance of EP in attachment and acceleration of biofilm by a number of different bacterial species is well established, the contribution of ALF to attachment in multispecies biofilm remains unknown. The study presented here aimed to investigate the role of TasA, a precursor for ALF, in cell-cell interactions in dual-species biofilms of Bacillus subtilis and Streptococcus mutans. Expression of major B. subtilis matrix operons was significantly up-regulated in the presence of S. mutans during different stages of biofilm formation, suggesting that the two species interacted and modulated gene ex

SUBMITTER: Duanis-Assaf D 

PROVIDER: S-EPMC6008451 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature