Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.

ABSTRACT:

Background

Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent.

Methods

We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as surrogates for endogenous oestrogen exposure on CRC risk. Weighted genetic risk scores based on 358 single-nucleotide polymorphisms associated with age at menarche and 51 single-nucleotide polymorphisms associated with age at menopause were used to estimate the association with CRC risk using logistic regression in 12,944 women diagnosed with CRC and 10,741 women without CRC fr

SUBMITTER: Neumeyer S 

PROVIDER: S-EPMC6008474 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature