Disrupted functional network integrity and flexibility after stroke: Relation to motor impairments.

ABSTRACT: Previous studies investigating brain activation present during upper limb movement after stroke have greatly detailed activity alterations in the ipsi- and contralesional primary motor cortices (M1). Despite considerable interest in M1, investigations into the integration and coordination of large-scale functional networks subserving motor, sensory, and cognitive control after stroke remain scarce. The purpose of this study was to assess non-static functional connectivity within whole-brain networks involved in the production of isometric, visually-paced hand grips. Seventeen stroke patients and 24 healthy controls underwent functional MRI while performing a series of 50 isometric hand grips with their affected hand (stroke patients) or dominant hand (control subjects). We used task-based

SUBMITTER: Lariviere S 

PROVIDER: S-EPMC6008503 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature