Increased Default Mode Network Connectivity in Obsessive-Compulsive Disorder During Reward Processing.

ABSTRACT: Objective: Obsessive-compulsive disorder (OCD) is characterized by anxiety-provoking, obsessive thoughts (i.e., obsessions) which patients react to with compulsive behaviors (i.e., compulsions). Due to the transient feeling of relief following the reduction of obsession-induced anxiety, compulsions are often described as relieving or even rewarding. Several studies investigated functional activation during reward processing in OCD, but findings are heterogeneous up to now and little is known about potential alterations in functional connectivity. Method: Against this background we studied OCD patients (n = 44) and healthy controls (n = 37) during the receipt of monetary reward by assessing both activation and functional connectivity. Results: Patients sho

SUBMITTER: Koch K 

PROVIDER: S-EPMC6008536 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature