Simulation and visualization of multiple KEGG pathways using BioNSi.

ABSTRACT: Motivation: Many biologists are discouraged from using network simulation tools because these require manual, often tedious network construction. This situation calls for building new tools or extending existing ones with the ability to import biological pathways previously deposited in databases and analyze them, in order to produce novel biological insights at the pathway level. Results: We have extended a network simulation tool (BioNSi), which now allows merging of multiple pathways from the KEGG pathway database into a single, coherent network, and visualizing its properties. Furthermore, the enhanced tool enables loading experimental expression data into the network and simulating its dynamics under various biological conditions or perturbations. As a proof of concept,

SUBMITTER: Yeheskel A 

PROVIDER: S-EPMC6008849 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature