Urethra-sparing stereotactic body radiotherapy for prostate cancer: how much can the rectal wall dose be reduced with or without an endorectal balloon?

ABSTRACT:

Background

This is a dosimetric comparative study intended to establish appropriate low-to-intermediate dose-constraints for the rectal wall (R_wall) in the context of a randomized phase-II trial on urethra-sparing stereotactic body radiotherapy (SBRT) for prostate cancer. The effect of plan optimization on low-to-intermediate R_wall dose and the potential benefit of an endorectal balloon (ERB) are investigated.

Methods

Ten prostate cancer patients, simulated with and without an ERB, were planned to receive 36.25Gy (7.25Gyx5) to the planning treatment volume (PTV) and 32.5Gy to the urethral planning risk volume (uPRV). Reference plans with and without the ERB, optimized with respect to PTV and uPRV coverage objectives and the organs at risk dose constrain

SUBMITTER: Dubouloz A 

PROVIDER: S-EPMC6008922 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature