TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association.

ABSTRACT:

Background

The breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts (TAFs). Emerging data indicate that TAFs increase production and signaling by TGF-β cytokines, while the role of TGF-β signaling in the regulation of tumor blood vessels is not fully understood. The current study presents evidence that TAFs enhance the organization of tumor blood capillaries, and TGF-β signaling plays an important role in this response.

Methods

Tumor vascularization was studied in xenograft models of breast carcinoma cells, alone and in combination with fibroblasts. TGF-β signaling in breast cancer cells was modulated by expression of kinase-inactive TGFBR1-K232R (dnTGFBR1) or constitutive-active TGFBR1-T204D (c

SUBMITTER: Zonneville J 

PROVIDER: S-EPMC6008941 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature