Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study.

ABSTRACT:

Objective

To use mendelian randomisation to investigate whether 25-hydroxyvitamin D concentration has a causal effect on gestational hypertension or pre-eclampsia.

Design

One and two sample mendelian randomisation analyses.

Setting

Two European pregnancy cohorts (Avon Longitudinal Study of Parents and Children, and Generation R Study), and two case-control studies (subgroup nested within the Norwegian Mother and Child Cohort Study, and the UK Genetics of Pre-eclampsia Study).

Participants

7389 women in a one sample mendelian randomisation analysis (751 with gestational hypertension and 135 with pre-eclampsia), and 3388 pre-eclampsia cases and 6059 controls in a two sample mendelian randomisation analysis.

Exposures

Single nucleotide polymorphisms in gene

SUBMITTER: Magnus MC 

PROVIDER: S-EPMC6008987 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature