Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.

ABSTRACT:

Background

As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer macrophages tightly control the angiogenic switch and progression to malignancy. ID4, a member of the ID (inhibitors of differentiation) family of proteins, is associated with a stem-like phenotype and poor prognosis in basal-like breast cancer. Moreover, ID4 favours angiogenesis by enhancing the expression of pro-angiogenic cytokines interleukin-8, CXCL1 and vascular endothelial growth factor. In the present study, we investigated whether ID4 protein exerts its pro-angiogenic function while also modulating the activity of tumour-associated macrophages in breast cancer.

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SUBMITTER: Donzelli S 

PROVIDER: S-EPMC6009061 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature