Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection.

ABSTRACT: Background:Maternally derived serum antibody and viral load are thought to influence disease severity in primary respiratory syncytial virus (RSV) infection. As part of the AsPIRES study of RSV pathogenesis, we correlated various serum antibody concentrations and viral load with disease severity. Methods:Serum neutralizing antibody titers and levels of immunoglobulin G (IgG) to RSV fusion protein (F), attachment proteins of RSV group A and B, the CX3C region of G, and nasal viral load were measured in 139 full-term previously healthy infants with primary RSV infection and correlated with illness severity. Results:Univariate analysis showed no relationship between measures of serum antibody and severity. However, a multivariate model adjusting for age at the time of infection found a signif

SUBMITTER: Walsh EE 

PROVIDER: S-EPMC6009588 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature