Translational control plays an important role in the adaptive heat-shock response of Streptomyces coelicolor.

ABSTRACT: Stress-induced adaptations require multiple levels of regulation in all organisms to repair cellular damage. In the present study we evaluated the genome-wide transcriptional and translational changes following heat stress exposure in the soil-dwelling model actinomycete bacterium, Streptomyces coelicolor. The combined analysis revealed an unprecedented level of translational control of gene expression, deduced through polysome profiling, in addition to transcriptional changes. Our data show little correlation between the transcriptome and 'translatome'; while an obvious downward trend in genome wide transcription was observed, polysome associated transcripts following heat-shock showed an opposite upward trend. A handful of key protein players, including the major molecular chaperones and

SUBMITTER: Bucca G 

PROVIDER: S-EPMC6009599 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature