Na⁺/Ca²⁺ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function.

ABSTRACT: An important feature of type 2 diabetes is a decrease in β-cell mass. Therefore, it is essential to find new approaches to stimulate β-cell proliferation. We have previously shown that heterozygous inactivation of the Na⁺/Ca²⁺ exchanger (isoform 1; NCX1), a protein responsible for Ca²⁺ extrusion from cells, increases β-cell proliferation, mass, and function in mice. Here, we show that Ncx1 inactivation also increases β-cell proliferation in 2-year-old mice and that NCX1 inhibition in adult mice by four small molecules of the benzoxyphenyl family stimulates β-cell proliferation both in vitro and in vivo. NCX1 inhibition by small interfering RNA or small molecules activates the calcineurin/nuclear factor

SUBMITTER: Papin J 

PROVIDER: S-EPMC6009611 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature