Quantitative Clinical Staging for Patients With Malignant Pleural Mesothelioma.

ABSTRACT:

Background

Analysis of the International Association for the Study of Lung Cancer (IASLC) Malignant Pleural Mesothelioma (MPM) database revealed that clinical (cTNM) staging minimally stratified survival and was discrepant with pathological (pTNM) staging. To improve prognostic classification of MPM, alternative staging models based on quantitative parameters were explored.

Methods

An institutional review board-approved MPM registry was queried to identify patients with available pathological and preoperative imaging data. Qualifying patients were randomly assigned to training and test sets in a 1:2 ratio. Computed cTNM and pTNM staging (AJCC Cancer Staging Manual, 7th ed.) were compared. Quantitative image analysis included tumor volume assessed from three-dimensional recon

SUBMITTER: Gill RR 

PROVIDER: S-EPMC6009654 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature