Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid-Induced Injury.

ABSTRACT:

Background & aims

Ileal bile acid absorption is mediated by uptake via the apical sodium-dependent bile acid transporter (ASBT), and export via the basolateral heteromeric organic solute transporter α-β (OSTα-OSTβ). In this study, we investigated the cytotoxic effects of enterocyte bile acid stasis in Ostα^-/- mice, including the temporal relationship between intestinal injury and initiation of the enterohepatic circulation of bile acids.

Methods

Ileal tissue morphometry, histology, markers of cell proliferation, gene, and protein expression were analyzed in male and female wild-type and Ostα^-/- mice at postnatal days 5, 10, 15, 20, and 30. Ostα^-/-Asbt^-/- mice were generated an

SUBMITTER: Ferrebee CB 

PROVIDER: S-EPMC6009794 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature