Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.

ABSTRACT:

Background

Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Here, we investigate whether a sub-set of triacylglycerols (TAGs) were associated with hepatic steatosis and whether they arise from de novo lipogenesis (DNL) from the consumption of carbohydrates.

Results

We conduct direct infusion mass spectrometry of lipids in plasma to study the association between specific TAGs and hepatic steatosis assessed by ultrasound and fatty liver index in volunteers from the UK-based Fenland Study and evaluate clustering of TAGs in the National Survey of Health and Development UK cohort. We find that TAGs contain

SUBMITTER: Sanders FWB 

PROVIDER: S-EPMC6009819 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature