Metabolomics and Metabolic Reprogramming in Kidney Cancer.

ABSTRACT: Kidney cancer, or renal cell carcinoma (RCC), is a disease of increasing incidence that commonly is seen in the general practice of nephrology. Despite this state of affairs, this fascinating and highly morbid disease frequently is under-represented, or even absent, from the curriculum of nephrologists in training and generally is underemphasized in national nephrology meetings, both scientific as well as clinical. Although classic concepts in cancer research in general had led to the concept that cancer is a disease resulting from mutations in the control of growth-regulating pathways, reinforced by the discovery of oncogenes, more contemporary research, particularly in kidney cancer, has uncovered changes in metabolic pathways mediated by those same genes that control tumor energetics an

SUBMITTER: Weiss RH 

PROVIDER: S-EPMC6009840 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature