Ontology highlight
ABSTRACT:
SUBMITTER: Xie X
PROVIDER: S-EPMC6010013 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Xie Xianrui X Cong Wei W Zhao Feng F Li Hongjuan H Xin Wenyu W Hou Guige G Wang Chunhua C
Journal of enzyme inhibition and medicinal chemistry 20181201 1
Twenty-four novel 5-phenyl-1,3,4-oxadiazole-2-thiol (POT) analogues, benzo[d]oxazole-2-thiol, benzo[d]thiazole-2-thiol and 5-methyl-1,3,4-thiadiazole-2-thiol-substituted N,N-bis(2-hydroxyethyl) quaternary ammonium salts (QAS) (5a-d, 6a-d, 7a-d, 10a-d, 13a-d, 16a-d) were prepared and characterised by FTIR, NMR and elemental analysis. Part of target compounds (5d, 6d, 7d, 10d, 13d, 16d) displayed potent antimicrobial effect against ten common pathogens (S. aureus, α-H-tococcus, β-H-tococcus, E. co ...[more]