Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis.

ABSTRACT:

Objectives

Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. We compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis.

Design

Cohort study.

Setting

The medical and surgical ICUs at an academic medical center.

Subjects

We enrolled 139 subjects who met two or more systemic inflammatory response syndrome (systemic inflammatory response syndrome) criteria and received new broad-spectrum antibacterial therapy.

Interventions

We assayed nine biomarkers (α-2 macroglobulin, C-reactive protein, fe

SUBMITTER: Kelly BJ 

PROVIDER: S-EPMC6010038 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature