Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosa.

ABSTRACT: Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase are important targets to treat obesity and diabetes, due to their deep correlation with insulin and leptin signalling, and glucose regulation. The methanol extract of Paulownia tomentosa fruits showed potent inhibition against both enzymes. Purification of this extract led to eight geranylated flavonoids (1-8) displaying dual inhibition of PTP1B and α-glucosidase. The isolated compounds were identified as flavanones (1-5) and dihydroflavonols (6-8). Inhibitory potencies of these compounds varied accordingly, but most of the compounds were highly effective against PTP1B (IC₅₀ = 1.9-8.2 μM) than α-glucosidase (IC₅₀ = 2.2-78.9 μM). Mimulone (1) was the most effective against PTP1B with IC₅₀ = 1.9 μM, wh

SUBMITTER: Song YH 

PROVIDER: S-EPMC6010085 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature