Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers.

ABSTRACT:

Background

Small nucleolar RNAs (snoRNAs) are small non-coding RNA sequences whose most studied function is ribosome biogenesis. The altered expression of snoRNA is observed in tumoral processes such as breast cancer and multiple myeloma. However, we have not found any references to snoRNAs in oral squamous cell carcinomas (OSCC) in the literature at the time this article was written.

Material and methods

We have analyzed snoRNA expression in frozen OSCC tissue samples and have compared them to healthy controls. RNA was extracted from a total of eight OSCC samples and eight control samples, measuring the differential expression of small RNAs with the Affymetrix^® miRNA 4.1 Array Plate microarray platform.

Results

Results were analyzed using the Transcriptome

SUBMITTER: Chamorro-Petronacci C 

PROVIDER: S-EPMC6010090 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature