Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI.

ABSTRACT:

Purpose

We optimized acido-chemical exchange saturation transfer (acidoCEST) magnetic resonance imaging (MRI), a method that measures extracellular pH (pHe), and translated this method to the radiology clinic to evaluate tumor acidosis.

Procedures

A CEST-FISP MRI protocol was used to image a flank SKOV3 tumor model. Bloch fitting modified to include the direct estimation of pH was developed to generate parametric maps of tumor pHe in the SKOV3 tumor model, a patient with high-grade invasive ductal carcinoma, and a patient with metastatic ovarian cancer. The acidoCEST MRI results of the patient with metastatic ovarian cancer were compared with DCE MRI and histopathology.

Results

The pHe maps of a flank model showed pHe measurements between 6.4 and 7.4, which matched wi

SUBMITTER: Jones KM 

PROVIDER: S-EPMC6010170 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature