Enhanced incentive motivation in obesity-prone rats is mediated by NAc core CP-AMPARs.

ABSTRACT: Studies in humans suggest that stronger incentive motivational responses to Pavlovian food cues may drive over-consumption leading to and maintaining obesity, particularly in susceptible individuals. However, whether this enhanced incentive motivation emerges as a consequence of obesity or rather precedes obesity is unknown. Moreover, while human imaging studies have provided important information about differences in striatal responsiveness between susceptible and non-susceptible individuals, the neural mechanisms mediating these behavioral differences are unknown. The Nucleus Accumbens (NAc) mediates cue-triggered reward seeking and activity in the NAc is enhanced in obesity-susceptible populations. Therefore here, we used selectively-bred obesity-prone and obesity-resistant rats to exam

SUBMITTER: Derman RC 

PROVIDER: S-EPMC6010194 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature