Neural correlates of top-down regulation and generation of negative affect in major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) is characterized by biased information processing that leads to difficulties regulating negative affect, which includes difficulty decreasing negative affect as well as maladaptively increasing negative affect via cognitive processes. To examine the underlying neural correlates, we scanned depressed and never-depressed adults as they completed a cognitive reappraisal task which required decreasing negative affect while viewing a negative image (down-regulation) and increasing negative affect while viewing a neutral image (emotion generation). Compared to control participants, MDD participants had less recruitment of the dorsal anterior cingulate (dACC) and supplementary motor area (SMA) during early phases of down-regulation, the latter associated with poore

SUBMITTER: Davis EG 

PROVIDER: S-EPMC6010205 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature