The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature.

ABSTRACT:

Background

Probiotics have generated intensive research interest in recent years as a novel mode of treatment for physical and mental illness. Nevertheless, the anxiolytic potential of probiotics remains unclear. The present systematic review and meta-analysis aimed to evaluate the clinical and preclinical (animal model) evidence regarding the effect of probiotic administration on anxiety.

Methods

The PubMed, PsycINFO, and Web of Science databases were reviewed for preclinical and clinical studies that met the defined inclusion and exclusion criteria. The effects of probiotics on anxiety-like behavior and symptoms of anxiety were analyzed by meta-analyses. Separate subgroup analyses were conducted on diseased versus healthy animals, specific preclinical probiotic species, an

SUBMITTER: Reis DJ 

PROVIDER: S-EPMC6010276 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature