Protective effects of a novel drug RC28-E blocking both VEGF and FGF2 on early diabetic rat retina.

ABSTRACT:

Aim

To investigate protective effects of a novel recombinant decoy receptor drug RC28-E on retinal damage in early diabetic rats.

Methods

The streptozotocin (STZ)-induced diabetic rats were randomly divided into 6 groups: diabetes mellitus (DM) group (saline, 3 µL/eye); RC28-E at low (0.33 µg/µL, 3 µL), medium (1 µg/µL, 3 µL), and high (3 µg/µL, 3 µL) dose groups; vascular endothelial growth factor (VEGF) Trap group (1 µg/µL, 3 µL); fibroblast growth factor (FGF) Trap group (1 µg/µL, 3 µL). Normal control group was included. At week 1 and 4 following diabetic induction, the rats were intravitreally injected with the corresponding solutions. At week 6 following the induction, apoptosis in retinal vessels was detected by TUNEL staining. Glial fibrillary acidic protein (GFAP) e

SUBMITTER: Yang QH 

PROVIDER: S-EPMC6010370 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature