NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells.

ABSTRACT: Emodin is a natural anthraquinone derivative that is present in various herbal preparations. The pharmacological effects of emodin include anticancer, hepatoprotective, anti-inflammatory, antioxidant and even antimicrobial activities. However, emodin also has been reported to induce hepatotoxicity, nephrotoxicity, genotoxicity and reproductive toxicity. The mechanism of emodin's adverse effects is complicated and currently not well understood. This study aimed to establish a cell metabonomic method to investigate the toxicity of emodin and explore its potential mechanism and relevant targets. In the present study, metabonomic profiles of cell extracts and cell culture media obtained using the ¹H NMR technique were used to assess emodin toxicity in HepG2 cells. Multivariate stati

SUBMITTER: Chen C 

PROVIDER: S-EPMC6010407 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature