A novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans.

ABSTRACT: Exercise has been known to reduce the risk of obesity and metabolic syndrome, but the mechanisms underlying many exercise benefits remain unclear. This is, in part, due to a lack of exercise paradigms in invertebrate model organisms that would allow rapid mechanistic studies to be conducted. Here we report a novel exercise paradigm in Caenorhabditis elegans (C. elegans) that can be implemented under standard laboratory conditions. Mechanical stimulus in the form of vibration was transduced to C. elegans grown on solid agar media using an acoustic actuator. One day post-exercise, the exercised animals showed greater physical fitness compared to the un-exercised controls. Despite having higher mitochondrial reactive oxygen species levels, no mitohormetic adaptations and lifespan extension we

SUBMITTER: Teo E 

PROVIDER: S-EPMC6010440 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature