Trajectories and changes in individual items of positive and negative syndrome scale among schizophrenia patients prior to impending relapse.

ABSTRACT: Effective early detection of impending relapse may offer opportunities for early interventions to prevent full relapse in schizophrenia patients. Previously reported early warning signs were not consistently validated by prospective studies. It remains unclear which symptoms are most predictive of relapse. To prioritize the symptoms to be captured by periodic self-report in technology-enabled remote assessment solutions for monitoring symptoms and detecting relapse early, we analyzed data from three relapse-prevention studies to identify individual items of the Positive and Negative Syndrome Scale (PANSS) that changed the most prior to relapse and to understand exactly when these symptoms manifested. Relapse was defined by a composite endpoint: hospitalization, suicidal/homicidal ideation,

SUBMITTER: Wang D 

PROVIDER: S-EPMC6010453 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature